SS18L1 Antibody, HRP conjugated

Datasheet

Code	CSB-PA022701LB01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SS18L1 Polyclonal antibody

Uniprot No.

O75177

Target Names

SS18L1

Alternative Names

Calcium-responsive transactivator antibody; CREST antibody; CREST_HUMAN antibody; KIAA0693 antibody; LP2261 antibody; MGC26711 antibody; MGC78386 antibody; sarcoma translocation gene on chromosome18like1 antibody; SS18 antibody; SS18-like protein 1 antibody; SS18L1 antibody; SS18L1 nBAF chromatin remodeling complex antibody; SSXT antibody; synovial sarcoma translocation antibody; synovial sarcoma translocation gene on chromosome 18-like 1 antibody; SYT homolog 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Calcium-responsive transactivator protein (47-396AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP.

Gene References into Functions

calcium-responsive transactivator and certain other amyotrophic lateral sclerosis-linked proteins share several features implicated in amyotrophic lateral sclerosis pathogenesis PMID: 25888396
Its mutation causes amyotrophic lateral sclerosis. PMID: 24360741
This study demonistrated that CREST mutations inhibited activity-dependent neurite outgrowth in primary neurons, and CREST associated with the ALS protein FUS. PMID: 23708140
A synovial sarcoma of classic morphology contained a novel t(20;X) SS18L1(strong homology to SS18 on Ch20)/SSX1 fusion transcript in which nucleotide 1216 (exon 10) of SS18L1 was fused in-frame with nucleotide 422 (exon 6) of SSX1. PMID: 12696068
analysis of the CREST domain that inhibits dendritic growth in cultured neurons PMID: 15866867
SS18 and SS18L1 genes map within co-linear DNA segments that may have evolved through a relatively recent genomic duplication event. PMID: 16484776

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Subcellular Location

Nucleus. Chromosome, centromere, kinetochore.

Protein Families

SS18 family

Tissue Specificity

Ubiquitous; with lowest levels in spleen.

Database Links

HGNC: 15592

OMIM: 606472

KEGG: hsa:26039

STRING: 9606.ENSP00000333012

UniGene: Hs.154429

Promotions

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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